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KMID : 0370020010150000005
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Chung-Ang Journal of Pharmacal Sciences
2001 Volume.15 No. 0 p.5 ~ p.10
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Synthesis of Indomethacin Amides
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Abstract
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Five indomethacin amides as potential nonsteroidal analgesic and antiinflammatory compounds were prepared. Indomethacin and hydroxysuccinimide were reacted with dicyclohexyl carbodiimide to give indomethacin active ester (4), which was treated with amines to yield indomethacin amides (5-9).
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